Correlation of Diabetic Nephropathy and HbA1C in Newly Diagnosed Type 2 Diabetic Patients of Western UP

Insulin resistance is characterized by a subnormal response to a given concentration of insulin and can be measured indirectly by a fasting insulin level. The prevalence of diabetes continues to grow worldwide, disease-related morbidity and mortality is emerging as major healthcare problems. Clearly, type 2 diabetes has a strong genetic component. Diabetic–nephropathy is the leading cause of end stage renal disease (ESRD) in US and a leading cause of diabetes mellitus related morbidity and mortality. Nephropathy complicates approximately 30% of type 2 diabetic patients. However no study has been performed that compared the HbA1c in type II diabetes mellitus with nephropathy to without nephropathy. Therefore aim of this study was to evaluate the glycosylated hemoglobin and their association with diabetic nephropathy in a western Uttar Pradesh. The body mass index (BMI) was calculated as weight (Kg) divided by height (m) squared. Venous blood was collected after 12 hours fasting into two test tubes; with no anticoagulant for serum creatinine, and with Ethylene Diamine Tetra Acetic Acid (EDTA) for HbA1c.we observed that Incidence of microalbuminuria increases with age as well as with increased duration of diabetes mellitus. Our study also evaluated relationship between diabetic retinopathy and nephropathy and found a significant correlation.